A car drove into the former Don Cherry's restaurant on Rideau Street Friday night after a two-car collision, leaving a large hole.
Police say a woman was involved in a collision with another car before her car slammed into the building.
Paramedics said the building was empty at the time and no one was injured.
The former restaurant is part of a building that now houses a University of Ottawa residence at the corner of Rideau Street and King Edward Avenue.
Ottawa police are investigating.