The Arizona Cardinals offense won't be at its best against the San Francisco 49ers on Sunday. The division leaders ruled out quarterback Kyler Murray and No. 1 wide receiver DeAndre Hopkins ahead of kickoff in the NFC West clash.
Murray suffered an ankle injury late in last week's loss to the Green Bay Packers. Hopkins played through a lingering hamstring injury in the same game that continues to hobble him. Both were considered game-time decisions leading up to the Sunday afternoon kickoff.
Colt McCoy will get the start in Murray's place while a receiving corps already missing A.J. Green (reserve/COVID-19 list) will depend more on Christian Kirk and Rondale Moore. The Cardinals will look to overcome the injuries to avoid a second straight loss after a 7-0 start. They enter Sunday's game tied with the 7-1 Los Angeles Rams atop the NFC West. The Rams will play the Tennessee Titans Sunday night.
The 3-4 49ers will look to avoid falling further behind in the NFC playoff race.