Murphy died Wednesday morning from leukemia, according to his publicist Domenick Nati. His death was first reported by celebrity website TMZ.
One popular segment — titled "Charlie Murphy's True Hollywood Stories" — saw him recount stories about past encounters with celebrities such as Prince and Rick James during his days as part of his younger brother Eddie's entourage.
More recently, Murphy had done voice work for animated series The Boondocks and the game Grand Theft Auto: San Andreas, appeared in the shows Black Jesus and Meet the Blacks and performed standup as part of the Comedy Get Down Tour alongside Cedric the Entertainer, Eddie Griffin, D.L. Hughley and George Lopez.
He had been slated to appear on the upcoming fourth season of the Starz drama series Power and was credited as a writer on several of his brother's movies, including Norbit, Paper Soldiers and Vampire in Brooklyn.
"He joined 'Power' for our upcoming season, and his talent shines in every scene," the channel said in a statement.
News of his death prompted a flood of reaction online from friends, colleagues, fans and even the U.S. Department of Defence, which paid tribute to Murphy, who had served in the U.S. navy.