Dallas Cowboys at Arizona Cardinals: Predictions, picks and odds for NFL Week 3 game

Editor’s note: Follow all the NFL Week 3 action with USA TODAY Sports’ live coverage.

One of the biggest betting mismatches of the NFL season takes place during Week 3 when the Dallas Cowboys (2-0) face the Arizona Cardinals (0-2).

It's been nothing but complete dominance from Dallas, as the Cowboys have scored easy victories from the New York teams by a combined score of 70-10. Micah Parsons and the defense have wrecked havoc, while the offense continues to put up points and make it even harder for teams to try and come back from.

Clearly a team in rebuild, it looked like Arizona would get a bright spot early in the year when they were up 20-0 at halftime against the reeling New York Giants. Instead, it blew its three score lead and lost 31-28 in a second half collapse. Now, Arizona fans are wondering when, and if, this team gets its first win of the season.

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Dallas Cowboys quarterback Dak Prescott (4) throws a pass in the game against the Arizona Cardinals at AT&T Stadium.
Dallas Cowboys quarterback Dak Prescott (4) throws a pass in the game against the Arizona Cardinals at AT&T Stadium.

Cardinals vs. Cowboys odds, moneyline, over/under

The Cowboys are favorites to defeat the Cardinals, according to the BetMGM NFL odds. Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2023.

  • Spread: Cowboys (-12.5)

  • Moneyline: Cowboys (-750); Cardinals (+525)

  • Over/under: 43

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NFL Week 3 odds, predictions and picks

49ers vs. Giants | Ravens vs. Colts | Browns vs. Titans | Lions vs. Falcons | Packers vs. Saints | Jaguars vs. Texans | Dolphins vs. Broncos | Vikings vs. Chargers | Jets vs. Patriots | Commanders vs. Bills | Seahawks vs. Panthers | Cardinals vs. Cowboys | Chiefs vs. Bears | Raiders vs. Steelers | Buccaneers vs. Eagles | Bengals vs. Rams

Lorenzo Reyes: Cowboys 33, Cardinals 3

This also has the makings of an absolute blowout. The Dallas pass rush is ferocious and the defense constantly generates turnovers. Dak Prescott is on a mission to quiet doubters about interceptions. The Cardinals have one of the worst rosters in the NFL. This one will get ugly.

Tyler Dragon: Cowboys 28, Cardinals 13

Micah Parsons is the early favorite for NFL Defensive Player of the Year. The Cowboys have the No. 1 ranked defense in the NFL. The Cowboys should feast on a talent deprived Cardinals team.

Victoria Hernandez: Cowboys 35, Cardinals 12

The Cowboys are the most dominant team in the NFL so far and that will not stop in Week 3 on the road. The Cardinals have been surprisingly productive without quarterback Kyler Murray, but they’re no threat to this top-notch defense. Dallas covers the spread easily.

Jordan Mendoza: Cowboys 38, Cardinals 9

This game could get really ugly and it could happen really fast. The Cowboys defense is going to feast on a struggling Arizona offense, and Dak Prescott should have no concerns when on the field. I wouldn't expect this game to be close.

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This article originally appeared on USA TODAY: Dallas Cowboys at Arizona Cardinals: Game predictions, picks, odds