A bonus-point victory will guarantee Ireland the title after they beat Italy last weekend, but England and in-form France are also chasing the Championship.
Chris Farrell steps up to take Henshaw’s place on the bench, meanwhile.
Also on the bench is scrum-half Jamison Gibson-Park, fit to take his spot after suffering a tight hamstring this week.
Loosehead prop Cian Healy will win his 100th cap in Paris.
“It will obviously be something quite special to myself and my family, and people around me,” Healy said. “I’m trying to pass it off and not have anything like that hang over me.
“There’s something much bigger than an individual merit to play for. I’m trying to brush it aside a bit at the moment and go towards that bigger thing.
“It’s an opportunity to win a medal, win a trophy and play with the lads. That’s the goal. Hopefully get selected and get the shot to do that.
"We go over with an unbelievably tough challenge, but it’s something that this group are hugely capable of and I think it’s something that will be needed.”
Coverage in association with QBE Insurance. QBE Insurance helps businesses build resilience through risk management and insurance. For more information go to QBEEUROPE.COM