With just over two minutes left on the clock, 36-year-old James caught the attention of the referee and brought him to two fans sitting courtside at Gainbridge Fieldhouse.
“This one right f****** here!”, James bellowed, pointing at a young man and woman.
The referee insisted the pair leave and TV cameras showed the woman exiting while performing a pout and rubbing away fake tears, but is unclear how their behaviour had irked James so much beforehand.
James finished with 39 points on 13-of-29 shooting and had six assists and five rebounds, with the Lakers playing without Anthony Davis because of flu-like symptoms.
On Sunday night in a victory at Detroit, James was ejected from for striking Pistons center Isaiah Stewart in the face and drawing blood.
The NBA suspended him a game and he sat out the Lakers’ loss at New York on Tuesday night.
The Lakers finished a five-game trip with their second victory in six games.
Malcolm Brogdon led Indiana with 28 points, and Chris Duarte had 17. Indiana never trailed until Malik Monk’s go-ahead 3 with 4:35 left in regulation.
Additional reporting by AP