Erik ten Hag's side make the trip to Goodison Park following the international break, looking to secure a third top-flight win on the bounce to continue to ease the pressure on their under-fire manager against a side reeling from being handed a 10-point deduction for allegedly breaching Premier League financial rules.
United then face a pivotal Champions League trip to Galatasaray before high-profile domestic meetings with Newcastle and Chelsea, making it imperative that their dire injury situation begins to improve for what is a crucial fixture run leading up to the festive period.
The Red Devils are already without Casemiro and Lisandro Martinez until the New Year, with Luke Shaw also still sidelined along with the likes of Jonny Evans, Tyrell Malacia and Amad Diallo, plus the unavailable Jadon Sancho.
Aaron Wan-Bissaka recently missed out again with illness, while Ten Hag's considerable fitness concerns were worsened again by Rasmus Hojlund and Christian Eriksen suffering injuries in the 1-0 win over Luton at Old Trafford.
Both players subsequently withdrew from the Denmark squad, with it since confirmed that Eriksen will be missing for around a month with a knee problem and Hojlund expected to return from a hamstring strain before the end of November.
As if that wasn't quite bad enough for Ten Hag, Marcus Rashford was substituted after a painful accidental collision with Trent Alexander-Arnold during England's 2-0 win over Malta at Wembley on Friday, while Andre Onana was also forced off late on with a shoulder issue in Cameroon's World Cup qualifier against Mauritius in Douala.
However, Three Lions boss Gareth Southgate said he thought Rashford - who joined up late for international duty due to personal reasons - was "probably okay" after the incident, while there appears to also be swift good news on Onana.
Fabrizio Romano reports that there is optimism around the first-choice goalkeeper, with his injury not believed to be anything serious.
Romano adds that Onana is expected to be fit and ready for United's important run of games coming up, while it remains to be seen if he will be back in action for Cameroon in their latest qualifier against Libya on Tuesday.