Ryan Reynolds and Rob McElhenney undergo colonoscopies to destigmatize the procedure

Ryan Reynolds and Rob McElhenney are hoping to kick colon cancer's ass.

The American Cancer Society recommends that people with an average risk of colorectal cancer start regular screenings at age 45. In efforts to raise awareness, the duo teamed up with Lead From Behind, a new initiative helping to spread the message that colon cancer is "the preventable cancer."

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