Police said an RV and a car collided on Highway 7, east of Alsask on Wednesday.
The crash resulted in both vehicles catching fire and left the driver of the car, a 40-year-old man from Saskatoon, dead.
An RCMP news release said his family was notified of his death, but no details were provided about his identity beyond his age and where he lived.
The driver of the RV sustained non-life-threatening injuries in the crash, which left the highway closed for about seven hours yesterday.
RCMP said officers from Kindersley and members of the forensic collision reconstruction unit were still investigating the incident.