Wednesday evening news briefing: Covid vaccine 'may not work for everyone'
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First coronavirus vaccine 'might not prevent infection'
The first Covid-19 vaccines are "likely to be imperfect" and "might not work for everyone", the chair of the UK Vaccine Taskforce has said. Kate Bingham said no vaccine in the history of medicine "has been as eagerly anticipated" but she cautioned against over-optimism and highlighted that a vaccine might not work for everyone, or for very long. Her piece in the Lancet comes as the Prime Minister faces growing pressure to implement tougher Covid measures. The former chief scientific adviser to the Government has said the number of people in hospital with Covid-19 could more than double within weeks.
Meanwhile, The Telegraph understands the whole of Nottinghamshire is to enter Tier 3 restrictions - but not until Friday. It all does not bode well for the chances of a normal Christmas. Here is what a Covid festive season could look like.
Across the Channel, President Emmanuel Macron is expected tonight to announce a national lockdown of at least a month from midnight on Thursday after 523 people died of Covid-19 on Tuesday, France's highest toll since April. Another 310 people have died in the UK from the virus in the last 24 hours. Meanwhile, Germany has announced a new range of far-reaching lockdown measures amid skyrocketing coronavirus cases across the country. Read what else is happening on the Covid continent.
Family drowned in Channel after warnings to stay put
A family of five, including a 15-month old boy, perished attempting to cross the Channel from France to Britain after warnings from family and a fellow migrant that it was too dangerous. The Kurdish family, from Sardasht city in Iran, are among up to seven people now feared dead in what is the worst disaster involving migrants attempting the perilous crossing. It is the first involving the deaths of children.
According to family members cited by Kurdish news reports, the father was Rasoul Irannazhad, a 35-year-old construction worker. He, his wife Shewa Mohammed Panahi, 25, and their children, Anita, Armin and Artin, aged nine, six, and 15 months respectively, who are pictured here, all died.
Duchess of Sussex's bid to end Mail on Sunday claim
The Duchess of Sussex has applied to have her privacy and copyright claims against the Mail on Sunday decided by a judge now, avoiding the need for a trial. Her legal team will tomorrow ask for summary judgment to be handed down in lieu of the trial, which is scheduled to begin in January, arguing the newspaper has no chance of success. It is also considering an application to strike out the privacy aspect of the case.
If successful, it would mean the Duchess, 39, would no longer have to give evidence, or face her father in court. Read on for details.
At a glance: Latest coronavirus headlines
Protect your body | Five ways to boost your immunity against Covid
'I'll ignore these rules' | Will you follow restrictions at Christmas?
Serving supper | Italians flock to enclave where restaurants still open
Kim Kardashian West | 'Cruel' boasts of 40th party on private island
Also in the news: Today's other headlines
Costly dog walk | When throwing a ball for a restless dog during the daily walk, it would never cross the owner's mind that this could result in a lawsuit and a £50,000 payout. Yet this was the case for investment banker Carina Read, who merrily chucked the toy for her cocker spaniel, Felix, causing him to run into the path of 70-year-old David Crane, who flew over the handlebars of his bike and onto the floor. Read more.
'Lost control' | Married police officer who strangled lover is jailed
Shark attack | Tourist, 12, and guide lose limbs at Sharm El-Sheikh
Slave trade | Chief curator of Historic Royal Palaces launches review
Crime victims | Why a quarter are pulling out of prosecutions
Potential antibiotic | Development from Komodo dragon blood
Around the world: Trump and Biden's family trees
Joe Biden channelled FDR in Warm Springs, Georgia, where he hopes to break the long-standing Republican hold on the state. His speech likened the crises in the US - a pandemic and an economic crash - to those faced by former president Franklin D Roosevelt. Ben Riley-Smith has this dispatch. But who is the man who could be the next US president? Katie Russell examines Mr Biden's family tree and how tragedy shaped him. Alice Hall gives the same treatment to the incumbent Donald Trump, and analyses the key influences that shaped the President.
Wednesday interview
'We were never trying to make idols of the characters in Hamilton'
As His Dark Materials returns, Lin-Manuel Miranda talks diversity, JK Rowling and #CancelHamilton with Chris Harvey
Comment and analysis
Jill Kirby | The conservative case against Rashford's school meals plan
Ross Clark | Deadly second wave proves lockdowns do not work
Patrick O'Flynn | The cure's beginning to look worse than the disease
Claire Cohen | Why Amy Coney Barrett is so difficult for women
Oliver Brown | No-one can believe a word Christian Coleman says
Editor's choice: Features and arts
Country living | Why fleeing the city may blow your budget
Unable to get out of first gear? | Welcome to midlife inertia - but it's no bad thing
Chrissy Teigen | I know the grief of miscarriage - she shouldn't have to hide it
Business and money briefing
Oxford Street | John Lewis has been granted permission to turn almost half of its flagship store on London’s Oxford Street into office space as it tries to restore the business to profitability. Read on for details.
Rolls-Royce | Should you worry or invest ahead of its 'rights issue'?
How we made it | Top tips from successful tech entrepreneurs
On top of markets | Live stocks and shares updates 24 hours a day
Sport briefing
Six Nations | Our writers have selected their XVs for England to take on Italy in Rome - and you can pick yours. Charlie Morgan analyses how breakdown changes will influence England's back-row selection.
Lions kit revealed | Shirt and prices ahead of South Africa tour
Tyrone Mings interview | 'Why did we take a knee? For real change'
James Corrigan | Golf's handicap issues mean overhaul is overdue
Tonight's TV
Damilola: The Boy Next Door, Channel 4, 9pm | This captivating film sees successful radio DJ Yinka Bokinni return to Peckham where 20 years ago, her neighbour and close friend Damilola Taylor was stabbed to death in a stairwell. Read on for more.
And finally... for this evening's downtime
'Keep calm and carry on – or die' | Did a cult art project inspire the Government's Covid posters? Cal Revely-Calder meets Richard Littler, creator of the fictional, warped town of 'Scarfolk'.