Seth Rogen: ‘Justin Bieber is a piece of s—’

Seth Rogen just insulted Justin Bieber in a superbad way. The 31-year-old comedian was none too impressed on Thursday when news broke that Bieber was arrested on DUI and drag racing charges in Miami.

"All jokes aside, Justin Bieber is a piece of s---," Rogen tweeted on Thursday. More than 100,000 people retweeted the message.

The B.C. native's comment came as a bit of a shock, considering he and the Biebs seemed pretty chummy at the 2011 MTV Video Music Awards (see photo above). But that same year, Rogen revealed in an interview with the U.K.'s Metro that people around him weren't superfans of the 19-year-old "Bad Day" singer.

"He really freaks out my girlfriend," Rogen said of his now-wife, Lauren Miller. "She says: 'I just don’t get it; it’s weird.'"

Meanwhile, Maude Apatow (yes, the daughter of director and producer Judd Apatow) seemed equally disturbed by Bieber on Thursday afternoon.

Hundreds of people, including Maude's famous dad, retweeted the message.

Bieber has one powerful celeb on his side. Lady Gaga issued a special call to her fans on Thursday to back up the Beliebers.

"I know everyone today is taking about Justin's arrest and all sorts of words and judgments are happening on the Internet. Everyone is entitled to their own opinion, and to stand up for themselves, but I think we should be supportive of Beliebers," Gaga wrote on her website. "They deserve, just like any other fan, to feel strong for each other and Justin so they can continue to share the bond they have through music."